Contact Information

 

Biography

Dr. Matthew Kostek is an Associate Professor in the Department of Physical Therapy where he teaches PA/DPT students a year-long Medical Physiology course.  He is the founder and director of the Laboratory of Muscle and Translational Therapeutics in the Rangos School of Health Sciences. His laboratory examines molecular mechanisms of muscle disease and how pharmacologic and exercise interventions affect cellular and whole-body rehabilitation outcomes.

Current research projects in the laboratory examine: 1) nanoparticle drug delivery to treat diseases (DMD, myositis) and muscle injury, and 2) Sex differences in muscle injury and repair and the effects of estrogen.  Dr. Kostek's laboratory has received federal, private foundation, and corporate funding and he has received the Dean's Award for Research Excellence in the Rangos School of Health Sciences.

Dr. Kostek is also a faculty member of the McGowan Institute of Regenerative Medicine at the University of Pittsburgh School of Medicine, a grant reviewer for NASA, an on-site reviewer for CAPTE, has authored numerous scientific articles and textbook chapters in muscle physiology and biochemistry, and is a member of the American Physiological Society and the American College of Sports Medicine (ACSM). He is a Fellow of the ACSM. Finally, as an extension and complement to his scientific endeavors, recent studies with collaborators in the neuroscience of pain led him to develop a study abroad class that integrates the mind and body. He leads students along the last ~100 miles of the Camino de Santiago in Spain where they explore and experience the history of "mindulful-walking," integrating the history and culture of Spain with the rich Catholic intellectural tradition of pilgrimage, culminating in a journey that goes within and beyond.

Education

  • Post-Doc, Molecular Genetics of Skeletal Muscle, George Washington University School of Medicine & Children's National Medical Center, Research Center for Genetic Medicine
  • Ph.D., Kinesiology, University of Maryland: Dissertation IGF1 genotypes and the effects on muscle function and cross-sectional area in sarcopenia 
  • MS, Clinical Exercise Physiology, Ball State University; Thesis: Changes in Basal Metabolic Rate and Fat-Free Mass in response to combined resistance and aerobic training in men
  • B.S., Exercise & Applied Science, Youngstown State University

Research Interests

  • Skeletal Muscle Physiology
  • DMD and genetic diseases of skeletal muscle
  • Interactions of pharmaceutics, sex hormones, and exercise interventions in skeletal muscle rehabilitation
  • Pilgrimage (Camino de Santiago)

 

School

American College of Sports Medicine, National Chair, Membership Committee, 2008-present

Membership Committee, 2005-present

Chair, Student Affairs Committee, 2004-2007

Student Affairs Committee, 2001-2007

Website Task Force, 2003

American College of Sports Medicine, Mid-Atlantic Chapter Student Representative to the Executive Committee, 2001-2003

Co-investigator: Pilot studies on quercetin's effect on health and performance

$406,848 (PI: Angela Murphy), 2008-2009

Coordinated and conducted all human muscle biopsies for this study examining the effects of quercetin supplementation on human muscle performance.

University of Maryland, College Park, Maryland

Study Coordinator: Gene Effects on Strength Responses to Aging, H&HS.R01AG018336,

$2,000,000 (PI: Ben Hurley), 1999-2004

Oversaw all aspects of study including subject recruitment, database management, testing and training of ~300 subjects, DNA extraction and storage, and management of graduate and undergraduate staff

Matthew Kostek, Kanneboyina Nagaraju, Ed Pistilli, Arpana Sali, San-Hui Lai, Brad Gordon, Tadamitsu Kishimoto and Yi-Wen Chen. IL-6 signaling blockade increases inflammation but does not improve muscle function in the mdx mouse.  BMC Musculoskeletal Disorders. In Press.

Brad Gordon, Diana Delgado, Matthew Kostek. Resveratrol decreases inflammation and increases utrophin gene expression in the mdx mouse model of Duchenne muscular dystrophy. Clinical Nutrition.  In Press.

James P White, Melissa J Puppa, Shuichi Sato, Song Gao, Robert L Price, John W Baynes, Matthew C Kostek, Lydia E Matesic and James A Carson Title  : IL-6 regulation on skeletal muscle mitochondrial remodeling during cancer cachexia in the ApcMin/+ mouse. Skeletal Muscle.  In Press

Brad Gordon, Diana Delgado, James White, James Carson, Matthew Kostek. Six1 and Six1 cofactor expression is altered during early skeletal muscle overload in mice. The Journal of Physiological Sciences.  In Press.

Sood S, Hanson ED, Delmonico MJ, Kostek MC, Hand BD, Roth SM, Hurley BF. Does insulin-like growth factor 1 genotype influence muscle power response to strength training in older men and women? European Journal of Applied Physiology, 2012 Feb;112(2):743-53

White JP, Baynes JW, Welle SL, Kostek MC, Matesic LE, Sato S, Carson JA.  The regulation of skeletal muscle protein turnover during the progression of cancer cachexia in the Apc(Min/+) mouse. PLoS One. 2011;6(9).

Delgado-Diaz DC, Gordon BS, Dompier T, Burgess S, Dumke C, Mazoué C, Caldwell T, Kostek MC. Therapeutic ultrasound affects IGF-1 splice variant expression in human skeletal muscle.   Am J Sports Med. 2011 Oct;39(10):2233-41.

Sood S, Hanson ED, Delmonico MJ, Kostek MC, Hand BD, Roth SM, Hurley BF.  Does insulin-like growth factor 1 genotype influence muscle power response to strength training in older men and women?  Eur J Appl Physiol. 2012 Feb;112(2):743-53

Kostek MC. Can aerobic training improve muscle strength and power in older men? J Aging Phys Act. 2010;18:14-26. Commentary: Clinical Journal of Sports Medicine, 2010 Sep;20(5):394-5.

Kostek MC and Delmonico MJ. Age related changes in adult muscle morphology. Current Aging Science. 2010. 2011 Apr 29.

Kostek MC, Joseph M. Devaney, Heather Gordish-Dressman, et al.  A polymorphism in the promoter region of IGF1 is associated with body composition and muscle function in women from the Health, Aging, and Body Composition Study and FMS cohort. European Journal of Applied Physiology. 2010 Sep;110(2):315-24

Delmonico MJ, Kostek MC, Johns J, Hurley BF, Conway JM.  Can Dual Energy X-Ray Absorptiometry Provide a Valid Assessment of Changes in Thigh Muscle Mass with Strength Training in Older Adults? European Journal of Clinical Nutrition. 2008 Dec; 62(12): 1372-8.

Hand BD, Kostek MC, Ferrell RE, Delmonico MJ, Douglass LW, Roth SM, Hagberg JM, Hurley BF.  Influence of promoter region variants of insulin-like growth factor pathway genes on the strength-training response of muscle phenotypes in older adults. Journal of Applied Physiology. 2007 Nov; 103(5):1678-87.

Kostek MC, Chen YW, Cuthbertson DJ, Shi R, Fedele MJ, Esser KA, Rennie MJ. Gene expression responses over 24h to lengthening and shortening contractions in human muscle: major changes in CSRP3, MUSTN1, SIX1 and FBXO32. Physiological Genomics. 2007 Sep;31(1):42-52.

Delmonico MJ, Kostek MC, Doldo NA, Hand BD, Walsh S, Conway JM, Carignan CR, Roth SM, Hurley BF.  Alpha-actinin-3 (ACTN3) R577X polymorphism influences knee extensor peak power response to strength training in older men and women. Journals of Gerontology: Series A, Biological and Medical Sciences. 2007 Feb.;62(2):206-12.

N Doldo, MJ Delmonico, JA Bailey, BD Hand, MC Kostek, KM Rabon-Smith, KS Menon, JM Conway, CR Carignan, Hurley B.  Muscle Power Quality: Does sex or race affect movement velocity in older adults?  Journal of Aging and Physical Activity. 2006 Oct;14(4):411-22.

Hand BD, Roth SM, Roltsch MH, Park JJ, Kostek MC, Ferrell RE, Brown MD.  AMPD1 gene polymorphism and the vasodilatory response to ischemia.  Life Sci. 2006 Sep 5;79(15):1413-8. Epub 2006 May 16.

Delmonico MJ, Kostek MC, Doldo NA, Hand BD, Bailey JA, Rabon-Stith KM, Conway JM, Carignan CR, Lang J, Hurley BF.  Effects of moderate-velocity strength training on peak muscle power and movement velocity: do women respond differently than men?

Journal of Applied Physiology. 2005 Nov;99(5):1712-8.

Kostek MC, Delmonico MJ, Reichel JB, Roth SM, Douglass L, Ferrell RE, Hurley BF.  Muscle strength response to strength training is influenced by insulin-like growth factor 1 genotype in older adults. Journal of Applied Physiology. 2005 Jun;98(6):2147-54.

Delmonico MJ, Ferrell RE, Meerasahib A, Martel GF, Roth SM, Kostek MC, Hurley BF.   Blood pressure response to strength training may be influenced by angiotensinogen A-20C and angiotensin II type I receptor A1166C genotypes in older men and women.

Journal of the American Geriatric Society. 2005 Feb;53(2):204-10.

Roltsch MH, Brown MD, Hand BD, Kostek MC, Phares DA, Huberty A, Douglass LW, Ferrell RE, Hagberg JM.  No association between ACE I/D polymorphism and cardiovascular hemodynamics during exercise in young women Int J Sports Med. 2005 Oct;26(8):638-44.

Rabon-Stith KM, Hagberg JM, Phares DA, Kostek MC, Delmonico MJ, Roth SM, Ferrell RE, Conway JM, Ryan AS, Hurley BF.Vitamin D receptor FokI genotype influences bone mineral density response to strength training, but not aerobic training.    Exp Physiol. 2005 Jul;90(4):653-61.

Hurley BF, Kostek MC.  Exercise interventions for Seniors: what training modality is best for health?  Orthopaedic Physical Therapy Clinics of North America. 2001;10:213-225.

Roth SM, Ivey F, Martel GF, Lemmer J, Hurlbut D, Siegel E, Metter J, Fleg J, Fozard J, Kostek MC, Wernick D, Hurley BF.  Muscle size responses to strength training in young and older men and women. Journal of the American Geriatric Society. 2001 Nov;49(11):1428-33.

Kostek MC, American Journal of Health and Fitness.  Can Strength training change your Metabolism? Vol.2 (Summer), 37-40; 2000. 

  • Alumni of the Year, Youngstown State University, Exercise Science Dept., 2010
  • Predoctoral Fellowship, University of Maryland/NIH, 2001-2004
  • Graduate Assistantship, Univeristy of Maryland, 2000-2001
  • Graduate Assistantship, Ball State Univeristy, 1997-1999
  • National Honor Society, Youngstown State University, 1996
  • All American Scholar, Youngstown State University, 1995-1996